The Danish Occupational Cohort (DOC*X) omfatter størstedelen af den danske arbejdsstyrke og dækker en periode på over 40 år. Kohorten giver unikke muligheder for forskning i sammenhænge mellem arbejdsliv, helbred og sociale forhold, baseret på omfattende data.
Nedenfor finder du metodeartiklen, som beskriver opbygningen og formålet med DOCX. Herudover finder du en række videnskabelige publikationer, hvor data fra DOCX er anvendt til at undersøge forskellige aspekter af arbejdsmiljø og sundhed. Artiklerne giver indsigt i både kohortens indhold og dens anvendelse i konkret forskning.
Beskrivelse af The Danish Occupational Cohort:
Forskningsprojekter:
Begtrup, L. M., Flachs, E. M., Wils, R. S., Mehlum, I. S., Bonde, J. P. E., Andersen, A. J., Frankel, H. N., Tøttenborg, S. S., Hougaard, K. S., & Sejbaek, C. S. (2025). Absence during pregnancy in the Danish workforce: occupational, industrial, and temporal trends in a nationwide register-based cohort study. Scandinavian Journal of Work, Environment and Health, 51(6), 483–494. https://doi.org/10.5271/sjweh.4245
Bonde, J. P. E., Begtrup, L. M., Coggon, D., Jensen, J. H., Flachs, E. M., Jakobsson, K., Nielsen, C., Nilsson, K., Rylander, L., Vilhelmsson, A., Petersen, K. U., & Tøttenborg, S. S. (2023). COVID-19-related hospital admission in spouses of partners in at-risk occupations. Scandinavian Journal of Work, Environment & Health, 49(3), 193–200. https://doi.org/10.5271/SJWEH.4080
Bonde, J. P. E., Begtrup, L. M., Jensen, J. H., Flachs, E. M., Jakobsson, K., Nielsen, C., Nilsson, K., Rylander, L., Vilhelmsson, A., Petersen, K. U., & Tøttenborg, S. S. (2023). Occupational risk of COVID-19 in foreign-born employees in Denmark. Occupational Medicine (Oxford, England). https://doi.org/10.1093/OCCMED/KQAD044
Bonde, J. P. E., Begtrup, L. M., Jensen, J. H., Flachs, E. M., Schlünssen, V., Kolstad, H. A., Jakobsson, K., Nielsen, C., Nilsson, K., Rylander, L., Vilhelmsson, A., Petersen, K. K. U., & Soegaard Toettenborg, S. (2023). Occupational risk of SARS-CoV-2 infection: a nationwide register-based study of the Danish workforce during the COVID-19 pandemic, 2020-2021. Occupational and Environmental Medicine, 80(4), 202–208. https://doi.org/10.1136/OEMED-2022-108713
Bonde, J. P. E., Flachs, E. M., Madsen, I. E. H., Petersen, S. B., Andersen, J. H., Hansen, J., Jørgensen, E. B., Kolstad, H., Holtermann, A., Schlünssen, V., & Svendsen, S. W. (2020). Acute myocardial infarction in relation to physical activities at work: a nationwide follow-up study based on job-exposure matrices. Scandinavian Journal of Work, Environment & Health, 46(3), 268–277. https://doi.org/10.5271/SJWEH.3863
Bonde, J. P. E., Sell, L., Flachs, E. M., Coggon, D., Albin, M., Hengel, K. M. O., Kolstad, H., Mehlum, I. S., Schlünssen, V., Solovieva, S., Torén, K., Jakobsson, K., Nielsen, C., Nilsson, K., Rylander, L., Petersen, K. U., & Tøttenborg, S. S. (2023). Occupational risk of COVID-19 related hospital admission in Denmark 2020-2021: a follow-up study. Scandinavian Journal of Work, Environment & Health, 49(1), 84–94. https://doi.org/10.5271/SJWEH.4063
Bonde, J. P. E., Sell, L., Jensen, J. H., Begtrup, L. M., Flachs, E. M. G., Jakobsson, K., Nielsen, C., Nilsson, K., Rylander, L., Petersen, K. U., & Tøttenborg, S. S. (2022). Occupational risk of COVID-19 across pandemic waves: a two-year national follow-up study of hospital admissions. Scandinavian Journal of Work, Environment & Health, 48(8), 672–677. https://doi.org/10.5271/SJWEH.4056
Bondo Petersen, S., Flachs, E. M., Prescott, E. I. B., Tjønneland, A., Osler, M., Andersen, I., Juel, K., Budz-Jørgensen, E., Kolstad, H. A., Schlünssen, V., & Bonde, J. P. (2018). Job-exposure matrices addressing lifestyle to be applied in register-based occupational health studies. Occupational and Environmental Medicine, 75(12), 890–897. https://doi.org/10.1136/OEMED-2018-104991
Boudigaard, S. H., Schlünssen, V., Vestergaard, J. M., Søndergaard, K., Torén, K., Peters, S., Kromhout, H., & Kolstad, H. A. (2021). Occupational exposure to respirable crystalline silica and risk of autoimmune rheumatic diseases: a nationwide cohort study. International Journal of Epidemiology, 50(4), 1213–1226. https://doi.org/10.1093/IJE/DYAA287
Brands, M. J., Loman, L., Lund, T. T., Flachs, E. M., Bültmann, U., & Schuttelaar, M. L. A. (2024). The association between wet work and hand eczema in the Dutch general population: Application of a job exposure matrix to the lifelines cohort study. Contact Dermatitis. https://doi.org/10.1111/cod.14687
Dalgaard, V. L., Willert, M. V., Kyndi, M., Vestergaard, J. M., Andersen, J. H., & Christiansen, D. H. (2023). Cohort Profile: The Danish Occupational Medicine Cohort-a nationwide cohort of patients with work-related disease. International Journal of Epidemiology, 52(4). https://doi.org/10.1093/IJE/DYAD013
Dornfeldt, M. M., Tøttenborg, S. S., Flachs, E. M., Begtrup, L. M., Madsen, I. E. H., Hougaard, K. S., & Sejbaek, C. S. (2025). Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma. International Archives of Occupational and Environmental Health, 98(1), 13–23. https://doi.org/10.1007/S00420-024-02107-6
Framke, E., Sørensen, J. K., Andersen, P. K., Svane-Petersen, A. C., Alexanderson, K., Bonde, J. P., Farrants, K., Flachs, E. M., Hanson, L. L. M., Nyberg, S. T., Villadsen, E., Kivimäki, M., Rugulies, R., & Madsen, I. E. H. (2020). Contribution of income and job strain to the association between education and cardiovascular disease in 1.6 million Danish employees. European Heart Journal, 41(11), 1164–1178. https://doi.org/10.1093/EURHEARTJ/EHZ870
Frankel, H. N., Flachs, E. M., Sejbaek, C. S., Petersen, J. A., Bonde, J. P., Mehlum, I. S., Korshøj, M., Peters, S., Svartengren, M., Hettiarachchi, P., Johansson, P. J., Burdorf, A., & Begtrup, L. M. (2025). Development of a quantitative job exposure matrix for standing, walking, and forward bending among pregnant workers – The PRECISE JEM. Scandinavian Journal of Work, Environment & Health, 51(6), 526–536. https://doi.org/10.5271/SJWEH.4252
Iversen, I. B., Vestergaard, J. M., Basinas, I., Ohlander, J., Peters, S., Bendstrup, E., Bonde, J. P. E., Schlünssen, V., Rasmussen, F., Stokholm, Z. A., Andersen, M. B., Kromhout, H., & Kolstad, H. A. (2024). Risk of hypersensitivity pneumonitis and other interstitial lung diseases following organic dust exposure. Thorax, 79(9), 853–860. https://doi.org/10.1136/thorax-2023-221275
Iversen, I. B., Vestergaard, J. M., Ohlander, J., Peters, S., Bendstrup, E., Bonde, J. P. E., Schlünssen, V., Bønløkke, J. H., Rasmussen, F., Stokholm, Z. A., Andersen, M. B., Kromhout, H., & Kolstad, H. A. (2024a). Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study. Occupational and Environmental Medicine, 81(6), 279–286. https://doi.org/10.1136/oemed-2023-108964
Iversen, I. B., Vestergaard, J. M., Ohlander, J., Peters, S., Bendstrup, E., Bonde, J. P. E., Schlünssen, V., Bønløkke, J. H., Rasmussen, F., Stokholm, Z. A., Andersen, M. B., Kromhout, H., & Kolstad, H. A. (2024b). The asbestos-asbestosis exposure-response relationship: a cohort study of the general working population. Scandinavian Journal of Work, Environment & Health, 50(5), 372–379. https://doi.org/10.5271/sjweh.4153
Johannesen, C. D. L., Flachs, E. M., Ebbehøj, N. E., Marott, J. L., Jensen, G. B., Nordestgaard, B. G., Schnohr, P., & Bonde, J. P. E. (2020). Sedentary work and risk of venous thromboembolism. Scandinavian Journal of Work, Environment & Health, 46(1), 69–76. https://doi.org/10.5271/SJWEH.3841
Korshøj, M., Svendsen, S. W., Hendriksen, P. F., Gupta, N., Holtermann, A., Andersen, J. H., Dalbøge, A., & Frost, P. (2022). Agreement between an expert-rated mini job exposure matrix of occupational biomechanical exposures to the lower body and technical measurements or observation: a method comparison study. BMJ Open, 12(12), e064035. https://doi.org/10.1136/BMJOPEN-2022-064035
Kristensen, I., Iversen, I. B., Fenger-Grøn, M., Kolstad, H. A., Würtz, E. T., Turner, M. C., Grandahl, K., Schmidt, S. A. J., & Stokholm, Z. A. (2025). Occupational solar ultraviolet radiation and incidence of non-melanoma skin cancer in a nationwide cohort. Environmental Pollution, 386. https://doi.org/10.1016/j.envpol.2025.12727
Lund, T., Flachs, E. M., Sørensen, J. A., Ebbehøj, N. E., Bonde, J. P., & Agner, T. (2019). A job-exposure matrix addressing hand exposure to wet work. International Archives of Occupational and Environmental Health, 92(7), 959–966. https://doi.org/10.1007/S00420-019-01435-2
Lund, T., Petersen, S. B., Flachs, E. M., Ebbehøj, N. E., Bonde, J. P., & Agner, T. (2020). Risk of work-related hand eczema in relation to wet work exposure. Scandinavian Journal of Work, Environment & Health, 46(4), 437–445. https://doi.org/10.5271/SJWEH.3876
Madsen, I. E. H., Gupta, N., Budtz-Jørgensen, E., Bonde, J. P., Framke, E., Flachs, E. M., Petersen, S. B., Svane-Petersen, A. C., Holtermann, A., & Rugulies, R. (2018). Physical work demands and psychosocial working conditions as predictors of musculoskeletal pain: a cohort study comparing self-reported and job exposure matrix measurements. Occupational and Environmental Medicine, 75(10), 752–758. https://doi.org/10.1136/OEMED-2018-105151
Nielsen, H. B., Gupta, N., Andersen, A. J., Dreyer, L. W., Flachs, E. M., Madsen, I. E. H., Kolstad, H. A., Kromhout, H., Sejbaek, C. S., & Hougaard, K. S. (2025). Physical work demands and risk of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus. A Danish longitudinal cohort study. Journal of Autoimmunity, 158, 103514. https://doi.org/10.1016/j.jaut.2025.103514
Nielsen, H. B., Sejbaek, C. S., Dreyer, L. W., Madsen, I. E. H., Flachs, E. M., & Hougaard, K. S. (2025). Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study. Scandinavian Journal of Work, Environment & Health, 51(3), 226–236.
Oude Hengel, K. M., Burdorf, A., Pronk, A., Schlünssen, V., Stokholm, Z. A., Kolstad, H. A., van Veldhoven, K., Basinas, I., van Tongeren, M., & Peters, S. (2022). Exposure to a SARS-CoV-2 infection at work: development of an international job exposure matrix (COVID-19-JEM). Scandinavian Journal of Work, Environment & Health, 48(1), 61–70. https://doi.org/10.5271/SJWEH.3998
Petersen, J. A., Brauer, C., Thygesen, L. C., Flachs, E. M., Lund, C. B., & Thomsen, J. F. (2022). Prospective, population-based study of occupational movements and postures of the neck as risk factors for cervical disc herniation. BMJ Open, 12(2). https://doi.org/10.1136/BMJOPEN-2021-053999
Petersen, J. A., Lund, C. B., Flachs, E. M., Petersen, R., Mikkelsen, S., & Thomsen, J. F. (2024). Validity of an expert-based job exposure matrix of hand-wrist physical exposures and their prospective associations with carpal tunnel syndrome. American Journal of Industrial Medicine, 67(10), 942–953. https://doi.org/10.1002/ajim.23651
Petersen, S. B., Flachs, E. M., Svendsen, S. W., Marott, J. L., Budtz-Jørgensen, E., Hansen, J., Stokholm, Z. A., Schlünssen, V., Andersen, J. H., & Bonde, J. P. (2020). Influence of errors in job codes on job exposure matrix-based exposure assessment in the register-based occupational cohort DOC*X. Scandinavian Journal of Work, Environment & Health, 46(3), 259–267. https://doi.org/10.5271/SJWEH.3857
Priskorn, L., Tøttenborg, S. S., Almstrup, K., Andersson, A. M., Axelsson, J., Bräuner, E. V., Elenkov, A., Freiesleben, N. la C., Giwercman, Y. L., Grøndahl, M. L., Hansen, A. H., Hansen, L. S., Henic, E., Kitlinski, M. L., Landersoe, S. K., Lindh, C., Løkkegaard, E. L., Malm, J., Olsen, K. W., … Giwercman, A. (2021). RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. Andrology, 9(6), 1828–1842. https://doi.org/10.1111/ANDR.13063
Remmen, L. N., Christiansen, D. H., Herttua, K., Klakk, H., & Berg-Beckhoff, G. (2023). The risk of an incident hospital contact with a musculoskeletal disorder in Danish occupational fishers: a register-based study. BMC Musculoskeletal Disorders, 24(1). https://doi.org/10.1186/S12891-023-06274-4
Rind, A., Kolstad, H. A., Ohlander, J., Peters, S., Kromhout, H., Iversen, I. B., & Stokholm, Z. A. (2025). Occupational exposure to respirable crystalline silica and incident glomerulonephritis. International Journal of Hygiene and Environmental Health, 269. https://doi.org/10.1016/j.ijheh.2025.114628
Ronsmans, S., Sørig Hougaard, K., Nawrot, T. S., Plusquin, M., Huaux, F., Jesús Cruz, M., Moldovan, H., Verpaele, S., Jayapala, M., Tunney, M., Humblet-Baron, S., Dirven, H., Cecilie Nygaard, U., Lindeman, B., Duale, N., Liston, A., Flachs, E. M., Kastaniegaard, K., Ketzel, M., … Yserbyt, J. (2022). The EXIMIOUS project-Mapping exposure-induced immune effects: connecting the exposome and the immunome. Environmental Epidemiology (Philadelphia, Pa.), 6(1), E193. https://doi.org/10.1097/EE9.0000000000000193
Rugulies, R., Framke, E., Sørensen, J. K., Svane-Petersen, A. C., Alexanderson, K., Bonde, J. P., Farrants, K., Flachs, E. M., Hanson, L. L. M., Nyberg, S. T., Fmedsci, M. K., & Madsen, I. E. H. (2020). Persistent and changing job strain and risk of coronary heart disease. A population-based cohort study of 1.6 million employees in Denmark. Scandinavian Journal of Work, Environment & Health, 46(5), 498–507. https://doi.org/10.5271/SJWEH.3891
Sejbaek, C. S., Flachs, E. M., Carøe, T. K., Meyer, H. W., Frederiksen, M., Frydendall, K. B., Wolkoff, P., Clausen, P. A., Hougaard, K. S., & Schlünssen, V. (2022). Professional cleaning and risk of asthma – a Danish nationwide register-based study. Scandinavian Journal of Work, Environment & Health, 48(2), 127–136. https://doi.org/10.5271/SJWEH.3997
Sejbaek, C. S., Madsen, I. E. H., Flachs, E. M., Bonde, J. P. E., Jensen, J. H., Mehlum, I. S., Rugulies, R., Soegaard Toettenborg, S., Hougaard, K. S., & Begtrup, L. M. (2025). Psychosocial working conditions during pregnancy and adverse pregnancy outcomes: a Danish nationwide register-based cohort study. Occupational and Environmental Medicine, 82(9), 429–436. https://doi.org/10.1136/oemed-2025-110195
Sejbaek, C. S., Nørtoft Frankel, H., Flachs, E. M., Hougaard, K. S., Mehlum, I. S., Soegaard Toettenborg, S., Madsen, I. E. H., Bonde, J. P. E., & Begtrup, L. M. (2025). Physical workload during pregnancy and adverse pregnancy outcomes: Results from a Danish nationwide occupational register-based pregnancy cohort (DOC∗X-Generation). Occupational and Environmental Medicine, 82(2), 53–60. https://doi.org/10.1136/oemed-2024-109908
Skaaby, S., Flachs, E. M., Lange, P., Schlünssen, V., Marott, J. L., Brauer, C., Çolak, Y., Afzal, S., Nordestgaard, B. G., Sadhra, S., Kurmi, O., & Bonde, J. P. E. (2021). Occupational inhalant exposures and longitudinal lung function decline. The European Respiratory Journal, 58(6). https://doi.org/10.1183/13993003.04341-2020
Skaaby, S., Flachs, E. M., Lange, P., Schlünssen, V., Marott, J. L., Brauer, C., Nordestgaard, B. G., Sadhra, S., Kurmi, O., & Bonde, J. P. E. (2020). Occupational exposures and exacerbations of asthma and COPD-A general population study. PloS One, 15(12). https://doi.org/10.1371/JOURNAL.PONE.0243826
Skaaby, S., Flachs, E. M., Lange, P., Schlünssen, V., Marott, J. L., Brauer, C., Nordestgaard, B. G., Sadhra, S., Kurmi, O., & Bonde, J. P. E. (2021). Chronic productive cough and inhalant occupational exposure-a study of the general population. International Archives of Occupational and Environmental Health, 94(5), 1033–1040. https://doi.org/10.1007/S00420-020-01634-2
Stokholm, Z. A., Erlandsen, M., Schlünssen, V., Basinas, I., Bonde, J. P., Peters, S., Brandt, J., Vestergaard, J. M., & Kolstad, H. A. (2020). A Quantitative General Population Job Exposure Matrix for Occupational Noise Exposure. Annals of Work Exposures and Health, 64(6), 604–613. https://doi.org/10.1093/ANNWEH/WXAA034
Thomsen, R. W., Riis, A. H., Flachs, E. M., Garabrant, D. H., Bonde, J. P. E., & Toft Sørensen, H. (2022). Risk of asbestosis, mesothelioma, other lung disease or death among motor vehicle mechanics: a 45-year Danish cohort study. Thorax, 77(5). https://doi.org/10.1136/THORAXJNL-2020-215041
van der Feltz, S., Peters, S., Pronk, A., Schlünssen, V., Stokholm, Z. A., Kolstad, H. A., van Veldhoven, K., Basinas, I., van Tongeren, M., Burdorf, A., & Oude Hengel, K. M. (2023). Validation of a COVID-19 Job Exposure Matrix (COVID-19-JEM) for Occupational Risk of a SARS-CoV-2 Infection at Work: Using Data of Dutch Workers. Annals of Work Exposures and Health, 67(1), 9–20. https://doi.org/10.1093/ANNWEH/WXAC032
van der Feltz, S., Schlünssen, V., Basinas, I., Begtrup, L. M., Burdorf, A., Bonde, J. P., Flachs, E. M., Peters, S., Pronk, A., Stokholm, Z. A., van Tongeren, M., van Veldhoven, K., Oude Hengel, K. M., & Kolstad, H. A. (2023). Associations between an international COVID-19 job exposure matrix and SARS-CoV-2 infection among 2 million workers in Denmark. Scandinavian Journal of Work, Environment & Health. https://doi.org/10.5271/SJWEH.4099
Vested, A., Basinas, I., Burdorf, A., Elholm, G., Heederik, D. J. J., Jacobsen, G. H., Kolstad, H. A., Kromhout, H., Omland, Ø., Sigsgaard, T., Thulstrup, A. M., Toft, G., Vestergaard, J. M., Wouters, I. M., & Schlünssen, V. (2019). A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD). Occupational and Environmental Medicine, 76(2), 105–113. https://doi.org/10.1136/OEMED-2018-105323
Vested, A., Schlünssen, V., Burdorf, A., Andersen, J. H., Christoffersen, J., Daugaard, S., Flachs, E. M., Garde, A. H., Hansen, Å. M., Markvart, J., Peters, S., Stokholm, Z., Vestergaard, J. M., Vistisen, H. T., & Kolstad, H. A. (2019). A Quantitative General Population Job Exposure Matrix for Occupational Daytime Light Exposure. Annals of Work Exposures and Health, 63(6), 666–678. https://doi.org/10.1093/ANNWEH/WXZ031
Willert, M. V., Christiansen, D. H., Dalgaard, L., Vestergaard, J. M., Andersen, J. H., & Kyndi, M. (2023). Developing prognostic models for health care utilization in patients with work-related mental health problems. BMC Health Services Research, 23(1), 834. https://doi.org/10.1186/S12913-023-09802-Z
Wils, R. S., Flachs, E. M., Stokholm, Z. A., Gustavsson, P., Plato, N., Kolstad, H. A., Sejbæk, C. S., Brauer, C., Schlünssen, V., Hougaard, K. S., Madsen, I. E. H., Rugulies, R., Ketzel, M., Hansen, J., Bang, C. N. F., Kromhout, H., Mehlum, I. S., & Bonde, J. P. (2025). Occupational exposure to diesel engine exhaust and first-time acute myocardial infarction: a nationwide register-based cohort study 1976-2018. European Journal of Preventive Cardiology, 32(8), 682–695. https://doi.org/10.1093/EURJPC/ZWAF022
Wils, R. S., Flachs, E. M., Stokholm, Z. A., Kromhout, H., Peters, S., Ohlander, J., Kolstad, H. A., Sejbæk, C. S., Schlünssen, V., Hougaard, K. S., Huitfeldt Madsen, I. E., Rugulies, R., Ketzel, M., Hansen, J., Furbo Bang, C. N., Gustavsson, P., Fleischer, N. L., Mehlum, I. S., & Bonde, J. P. (2025). Occupational exposure to respirable crystalline quartz and the risk of incident acute myocardial infarction. International Journal of Environmental Health Research, 1–13. https://doi.org/10.1080/09603123.2025.2482064
Wils, R. S., Nielsen, H. B., Flachs, E. M., Andersen, A. J., Dreyer, L. W., Ketzel, M., Brandt, J., Khan, J., Vogel, U., Sejbaek, C. S., & Hougaard, K. S. (2025). Air pollution and risk of rheumatoid arthritis – A Danish register-based cohort study. Environmental Toxicology and Pharmacology, 120, 104855. https://doi.org/10.1016/j.etap.2025.104855
Aavang Petersen, J., Brauer, C., Thygesen, L. C., Flachs, E. M., Bach Lund, C., & Froelund Thomsen, J. (2022). Risk of pain in the neck and shoulders and job change among hairdressers: a combined questionnaire and register-based Danish prospective cohort study. International Archives of Occupational and Environmental Health, 95(3), 709–719. https://doi.org/10.1007/S00420-021-01753-4
Aavang Petersen, J., Brauer, C., Thygesen, L. C., Flachs, E. M., Lund, C. B., & Thomsen, J. F. (2022). Repetitive and forceful movements of the hand as predictors of treatment for pain in the distal upper extremities. Occupational and Environmental Medicine, 79(1), 55–62. https://doi.org/10.1136/OEMED-2021-107543
Udover publikationer er det også muligt at få en oversigt over afsluttede og igangværende projekter med Danish Occupational Cohort.
